Dr. Seungchan Kim is a Chief Scientist and Executive Professor at the Department of Electrical and Computer Engineering and the Director of the CRI Center for Computational Systems Biology at the Prairie View A&M University (PVAMU).  Prior to this appointment, he was the Head of Biocomputing Unit and an Associate Professor at Integrated Cancer Genomics Division of Translational Genomics Research Institute (TGen).  He was one of the founding faculty members of TGen, founded in 2002, by Dr. Trent, then-Scientific Director of the National Human Genome Research Institute at the National Institutes of Health, leading computational systems biology research at the institute.  He was also an Assistant Professor in the School of Computing, Informatics, Decision Systems Engineering (CIDSE) at the Arizona State University from 2004 till 2011.  Dr. Kim received B.S. and M.S. degrees in Agriculture Engineering from the Seoul National University, and Ph.D. in Electrical Engineering from the Texas A&M University. He also got his post-doctoral training at the Cancer Genetics Branch of National Human Genome Research Institute.
Dr. Kim’s research interests include: 1) mathematical modeling of genetic regulatory networks, 2) development of computational methods to analyze multitude of high throughput multi-omics data to identify disease biomarkers, and 3) computational models to diagnose patients or predict patient outcomes, for example, disease subtypes or drug response. His studies have had a large influence on the development of computational tools to study underlying mechanisms for cancer development and better understand the molecular mechanisms behind cancer biology and biological systems.
Current projects
  - Molecular and Genetic Analysis of Axillary Bud Dormancy and Outgrowth in Sorghum and Maize 
to Identify Shoot Branching Genes 
[more info] |
[more info 2]
    
      - USDA-NIFA (05/2022 – 04/2025)
 
      - Tesfamichael Kebrom (PI); Role: co-PI
 
    
   
  - Engineering Methanotrophy for Carbon Capture and Utilization
[more info]
    
      - NTESS/Sandia Lab (01/14/2022 – 09/30/2024)
 
      - Seungchan Kim (PI)
 
    
   
  - GET-PHIT: The PHIT Workforce Development Program: Creating a diverse and inclusive 
health information technology (IT) workforce in Texas
[more info] |
[more info 2] |
[more info 3]
    
      - Office of National Coordinator for HIT (ONC) via UT Health Science Center Houston (09/21/2021 – 09/20/2022)
 
      - Eric Boerwinkle (PI); Role - co-I (PVAMU sub PI)
 
    
   
  - Physiological and Molecular Characterization of Tillering, Internode Elongation, and 
Stunting in the Tiller Inhibition (tin) Mutant Wheat
[more info] |
[more info 2]
    
      - USDA-NIFA (01/2021 - 12/2022)
 
      - Tesfamichael Kebrom (PI); Role: co-PI
 
    
   
  - Development of Classifiers for Novel Bladder Cancer Subtypes
[more info]
    
      - DOD/CDMRP (07/2019 - 06/2023)
 
      - Woonyoung Choi & Seungchan Kim (MPI); Role: MPI
 
    
   
  - Noncoding RNA Biomarkers for Noninvasive and Early Detection of Pancreatic Cancer
[more info]
    
      - NIH/NCI via City of Hope (09/2017 - 07/2023)
 
      - Ajay Goel & Dan von Hoff (MPI); Role: co-I (PVAMU sub PI)
 
    
   
		 
		
		
		
		
		
		
		Recent Papers
		
		
		
		
		
		
		
		Reversal of inflammatory reprogramming by vasodilator agents in pulmonary hypertension
		
		
		
		
		
		
Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension
		
		
		
		
		
		
		
		
		
		
Identification of Lineage-specific Transcriptional Factor-defined Molecular Subtypes in Small Cell Bladder Cancer
		
		
		
		
		
		
Calibrated bagging deep learning for image semantic segmentation: A case study on COVID-19 chest X-ray image
		
		
		
		
		
		
		
		
		
		
An Exosome-based Transcriptomic Signature for Noninvasive, Early Detection of Patients With Pancreatic Ductal Adenocarcinoma: A Multicenter Cohort Study
		
		
		
		
		
		
		
		
		
		
Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension
		
		
		
		
		
		
Semi-supervised Learning for COVID-19 Image Classification via ResNet
		
		
		
		
RNA sequencing of whole blood reveals early alterations in immune cells and gene expression in Parkinson’s disease
		
		
		
		
		
		
		
		
		
		
Frataxin deficiency promotes endothelial senescence in pulmonary hypertension
		
		
		
		
		
		
Matrix Stiffening Induces a Pathogenic QKI-miR-7-SRSF1 Signaling Axis in Pulmonary Arterial Endothelial Cells
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function: Implications for Diagnostic Marker Development in Pulmonary Arterial Hypertension
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
Extracellular microRNAs in blood differentiate between ischaemic and haemorrhagic stroke subtypes
		
		
		
		
		
		
Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas
		
		
		
		
		
		
 Probing glioblastoma and its microenvironment using single-nucleus and single-cell sequencing
		
		
		
		
		
		
		
		
		
		
		
		
Leveraging Spatial Variation in Tumor Purity for Improved Somatic Variant Calling of Archival Tumor Only Samples
		
		
		
		
		
		
Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome
		
		
		
		
		
		
		
		
		
		
		
		
		
		
Phenotype Classification Using Moment Features of Single-Cell Data
		
		
		
		
GPU-accelerated differential dependency network analysis
		
		
		
		
		
		
Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation
		
		
		
		
		
		
		
		
		
		
		
		
		
		
Contextualization of drug-mediator relations using evidence networks
		
		
		
		
		
		
		
			
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						Xishaung Dong, Ph.D., prompoted to Associate Professor
					
				
				
			
				
					
						
Ms. Jalyn D Beaty successfully presented her MS project
					
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
					
						
Dr. Kim co-leads NIH T32 training grant for AI-Precision Nutrition Research to Promote Nutrition Health Equity among Underserved Populations
					
				
				
			
				
					
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
					
				
				
			
				
					
						
Dr. Kim awarded a collaborative grant with UPMC team to identify anti-inflammatory and anti-fibrotic effects of Tyvaso in WSPH Group 3 pulmonary hypertension
					
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
					
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
					
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
					
				
				
			
				
				
			
				
					
						
Dr. Kim leads PVAMU team to collaborate with UT Health for GET PHIT award
					
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
					
						
Dr. Dong awarded Faculty-RISE Graduate Research Award - Division of Research & Innovation
					
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
					
						
Dr. Kebrom awarded a $200,000 research grant from the National Institute of Food and Agriculture (NIFA), United Stated Department of Agriculture (USDA)
					
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
					
						
Dr. Dong awarded a curriculum development grant for collaboration with NVIDIA on the DLI Data Science Teaching Kit with RAPIDS
					
				
				
			
				
					
						
Special Issue 'Genomic Fabric Remodeling in Neurological Disorders'
					
				
				
			
				
				
			
				
				
			
				
					
						
Dr. Joy awarded with Faculty RISE-Undergraduate Research Award - Division of Research & Innovation
					
				
				
			
				
				
			
				
					
						
Dr. Dong awarded with Faculty RISE-Graduate Research Award - Division of Research & Innovation
					
				
				
			
				
					
						
Department of Electrical and Computer Engineering (Dr. Dong) gets a gift ($25,000) from Intel Corporation for Curriculum Development
					
				
				
			
				
				
			
				
					
						
Dr. Dong awarded with RAPID to study COVID-19 with Medical Images
					
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
					
						
2019 IEEE BIBM Workshop - Single Cell -Omics: Challenges and Opportunities (BIBM-SCOMICS)
					
				
				
			
				
				
			
				
					
						
Hiring a post-doctoral fellow for Computational Biology
					
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
					
						
FIE Funding for Dr. Tesfamichael Kebrom
					
				
				
			
				
				
			
				
					
						
[DOD-CDMRP Translational Team Science Award] Development of Classifiers for Novel Bladder Cancer Subtypes
					
				
				
			
				
				
			
				
				
			
				
					
						
Dr. Kebrom joins CCSB and CARC, as a Research Scientist for Plant Systems Biology
					
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
				
			
				
					
				
				
			
				
					
				
				
			
				
					
				
				
			
				
					
						
CCSB@PVAMU website is up and running
					
				
				
			
				
					
						
CCSB Genomics Lab certified for BSL2
					
				
				
			
				
					
						
Dr. Xishuang Dong accepted a tenure-track faculty position (ECE) for CCSB@PVAMU
					
				
				
			
				
					
						
CCSB Signage Goes Up
					
				
				
			
				
					
						
Dr. Youngblood awarded NSF HBCU-RIA grant in collaboration with CCSB@PVAMU - first of many more to come!
					
				
				
			
				
					
						
First sequencing at CCSB@PVAMU - Humble Start
					
				
				
			
				
					
						
Drs. Lijuan Qian (PI), Xiangfang Li, Seungchan Kim and Pamela Obiomon awarded NSF-RISE grant.