Dumitru Andrei Iacobas

Research Professor – Director Personalized Genomics Laboratory



I am PhD in (Bio)Physics of the University of Bucharest, Romania. I came at PVAMU CRI-CCSB attracted by the research conditions offered by the generous budget, space and institutional support (and also to be closer to my daughter and grandchildren). I brought a fully equipped (~$150,000) microarray laboratory and the experience of 37 years on faculty positions at 2 major medical schools from Romania (1981-2001 at Carol Davila and Ovidius) and 2 from NY (2001-1013 at Albert Einstein College of Medicine and 2013-2017 at New York Medical College). Since 2001, when immigrated in the USA with an O1 (outstanding) visa sponsored by Einstein’s Department of Neuroscience, I have received over $1.5 mil in research funding as PI/MPI and participated as Co-Pi/Investigator at other $14 mil funded research grants. I was involved in all branches of genomics research: technology development, optimization of experimental design and wet protocols, taking care of lab animal colonies and cell cultures, performing experiments, data analysis and development of new algorithms, analytical tools and software.

So far, I have 3 patents, 7 books (22 editions in Romanian, English, Spanish and Greek), 86 peer-reviewed articles, 27 book chapters and 79 genomic data sets deposited in the Gene Expression Omnibus (GEO) of the NIH National Center for Biotechnology Information (NCBI). Out of these total of 202 publications, 33 were produced as single author, 81 as the first author and 19 as the last author. I gave invited talks and seminars at academic institutions (from Argentina, Brazil, Canada, Chile, Colombia, England, France, Germany, Greece, Italy, Panama, Portugal, Romania, Sweden, USA, Venezuela) and numerous talk-shows at (Romanian) national and local television and radio stations. My writings include also 3 philosophical novels, countless poetry and essays, a drama sequel and 2 musicals played by student theaters.

Recent Papers

PPAR-γ activation enhances myelination and neurological recovery in premature rabbits with intraventricular hemorrhage

TWEAKing the Hippocampus: The Effects of TWEAK on the Genomic Fabric of the Hippocampus in a Neuropsychiatric Lupus Mouse Model

A Personalized Genomics Approach of the Prostate Cancer

Retinal Genomic Fabric Remodeling after Optic Nerve Injury

Remodeling of Neurotransmission, Chemokine, and PI3K-AKT Signaling Genomic Fabrics in Neuropsychiatric Systemic Lupus Erythematosus

Transcriptomic uniqueness and commonality of the ion channels and transporters in the four heart chambers

Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach

Trypanosoma cruzi Promotes Transcriptomic Remodeling of the JAK/STAT Signaling and Cell Cycle Pathways in Myoblasts

Cellular Environment Remodels the Genomic Fabrics of Functional Pathways in Astrocytes

Pulmonary Hypertension Remodels the Genomic Fabrics of Major Functional Pathways

Commentary on The Gene Master Regulators GMR Approach Provides Legitimate Targets for Personalized, Time-Sensitive Cancer Gene Therapy

Coordinated Activity of Transcriptional Networks Responding to the Pattern of Action Potential Firing in Neurons

The Gene Master Regulators (GMR) Approach Provides Legitimate Targets for Personalized, Time-Sensitive Cancer Gene Therapy

Expression of Genes Encoding for Xenobiotic Metabolism after Exposure to Dialkylnitrosamines in the Chicken Egg Genotoxicity Alternative Model

Regeneration of Neurotransmission Transcriptome in a Model of Epileptic Encephalopathy after Antiinflammatory Treatment

Estrogen Protects Neurotransmission Transcriptome During Status Epilepticus

ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms

Gene master regulators of papillary and anaplastic thyroid cancers

Functional genomic fabrics are remodeled in a mouse model of Chagasic cardiomyopathy and restored following cell therapy